# LLM Prompt for Full Research Manuscript

## Prompt Instructions

You are a medical research writer specializing in cardiovascular pharmacology and clinical trials. Write a complete research manuscript for the following study. Use formal academic language appropriate for submission to a peer-reviewed medical journal such as the Journal of the American Heart Association or Circulation.

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## Study Details to Include:

**Title:** Evaluating LDL-C Reduction and Safety of Local vs Original Atorvastatin, With Exercise as an Adjunct, in Adults ≥35 Years: A Synthetic Cohort Study

**Study Design:** Randomized, factorial (2×2), open-label, controlled trial

**Population:** Adults ≥35 years with LDL-C ≥10% above guideline targets

**Interventions:** 
- Pharmacological: Original atorvastatin 10mg vs Local-made atorvastatin 10mg daily
- Lifestyle: Structured exercise advice (≥150 min/week moderate intensity) vs standard care

**Primary Outcome:** Mean change in LDL-C (mg/dL) from baseline to 3 months

**Secondary Outcomes:** 
- Proportion reaching LDL-C targets (<100 mg/dL moderate risk; <70 mg/dL high risk)
- Mean change in HDL-C and triglycerides
- Safety outcomes: ALT, CK levels, muscle-related symptoms

**Sample Size:** xxxx participants randomized 1:1:1:1 into 4 groups

**Statistical Analysis:** ANCOVA with baseline LDL-C as covariate; non-inferiority margin 5 mg/dL

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## Manuscript Structure Required:

### 1. TITLE PAGE
- Complete title
- Author names and affiliations (use placeholder: [Author Names and Affiliations])
- Corresponding author details
- Word count
- Key words (5-6 terms)

### 2. ABSTRACT (250 words maximum)
Structure with subheadings:
- **Background and Objectives**
- **Methods** 
- **Results**
- **Conclusions**
- **Clinical Trial Registration:** [Registry Number]

### 3. INTRODUCTION
- Cardiovascular disease burden and LDL-C as risk factor
- Current atorvastatin use and generic vs original formulations
- Role of exercise in lipid management
- Evidence gaps and rationale for this study
- Study objectives and hypotheses

### 4. METHODS
- **Study Design and Setting**
- **Participants:** Inclusion/exclusion criteria, recruitment
- **Randomization and Allocation**
- **Interventions:** Drug protocols and exercise counseling details
- **Outcome Measures:** Primary and secondary endpoints
- **Data Collection:** Baseline and follow-up procedures
- **Statistical Analysis:** Power calculation, analytical methods
- **Ethical Considerations**

### 5. RESULTS
- **Participant Flow:** Enrollment, randomization, completion rates
- **Baseline Characteristics:** Demographics, clinical parameters by group
- **Primary Outcome:** LDL-C changes with statistical significance
- **Secondary Outcomes:** HDL-C, triglycerides, target attainment
- **Safety Outcomes:** ALT, CK, adverse events
- **Subgroup Analyses:** If applicable

### 6. DISCUSSION
- **Key Findings:** Summary of main results
- **Comparison with Previous Studies:** Literature context
- **Clinical Implications:** Practice and policy implications
- **Mechanism Discussion:** Potential explanations for findings
- **Strengths and Limitations**
- **Future Research Directions**

### 7. CONCLUSIONS
- Clear, concise summary of study conclusions
- Clinical practice implications

### 8. REFERENCES
- Use Vancouver style numbering
- Include recent relevant literature (placeholder: [References 1-XX])

### 9. TABLES AND FIGURES
Create placeholders for:
- **Table 1:** Baseline characteristics by treatment group
- **Table 2:** Primary and secondary outcomes
- **Table 3:** Safety outcomes and adverse events
- **Figure 1:** CONSORT flow diagram
- **Figure 2:** LDL-C changes by treatment group (box plots)
- **Figure 3:** Time-course of lipid parameters

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## Key Results to Incorporate:
(Use xxxx for specific numbers)

- **Enrollment:** xxxx participants screened, xxxx randomized
- **Primary outcome:** Exercise groups showed xxxx mg/dL greater LDL-C reduction vs no exercise
- **Drug comparison:** Non-inferiority demonstrated (difference xxxx mg/dL, 95% CI: xxxx to xxxx)
- **Safety:** No significant differences in ALT, CK elevations between groups
- **Target attainment:** xxxx% reached LDL-C targets in exercise groups vs xxxx% in no exercise groups

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## Writing Style Requirements:

1. **Academic tone:** Formal, objective, evidence-based
2. **Statistical reporting:** Include confidence intervals, p-values, effect sizes
3. **Clinical focus:** Emphasize practical implications for patient care
4. **Balanced discussion:** Acknowledge limitations and alternative interpretations
5. **CONSORT compliance:** Follow clinical trial reporting guidelines
6. **Journal formatting:** Standard IMRaD structure with appropriate subheadings

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## Special Instructions:

- Use placeholder "xxxx" for all specific numerical data
- Include appropriate disclaimers about synthetic data if this is for educational purposes
- Ensure non-inferiority analysis is properly explained and interpreted
- Discuss both drug equivalence and exercise benefit findings
- Address cost-effectiveness implications in discussion
- Include appropriate statistical methodology descriptions
- Follow medical journal citation format throughout

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**Generate the complete manuscript now, ensuring all sections are thoroughly developed and professionally written for peer review submission.**